Synthesis of Quinolone Antibiotic Analogues: A Multistep Synthetic Chemistry Experiment for Undergraduates

A multistep synthesis of quinolone antibiotic analogues was developed as a laboratory experiment for intermediate/advanced undergraduate students. Students can synthesize range desfluoroenoxacin via five-step sequence. The includes key practical techniques including thin-layer chromatography (TLC), liquid–liquid extraction, trituration, recrystallization, and the characterization compounds by IR NMR spectroscopy. provides an opportunity students to carry out fundamental organic chemistry transformations from curriculum such preparation acyl chlorides, 1,4-conjugate addition–elimination, heterocycle synthesis, nucleophilic aromatic substitution, ester hydrolysis. sequence does not require column be adapted settings.